abbomax/Tau (pS202)/100ug/620-650,abbomax,,abbomax,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：abbomax/Tau (pS202)/100ug/620-650

产品编号：620-650

市场价：¥0.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>内参抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$345.00

品牌： abbomax

公司：abbomax

公司分类：

商品介绍

Tau (pS202)

microtubule-associated protein tau; MAPT

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Product Preparation

A synthetic peptide surrounding of –PGSPG-of human Tau protein with a phosphorylation site Serine 202. This sequence is identical to human, mouse, rat and bovine.

Background

Tau is a microtubule-associated phosphoprotein (MAP), localized in neuronal axons. It promotes tubulin polymerization and stabilizes microtubules. Tau proteins constitute a family of six isoforms which range from 352 to 441 amino acids. The tau variants differ from each other by the presence of either three or four repeat-regions in the carboxy-terminal part of the molecule and the absence or presence of one or two inserts in the amino-terminal part. Tau is hyperphosphorylated by ERK, GSK-3, TPKII and CDK5, at least thirty phosphorylation sites have been described, including Thr39, Ser46, Thr50, Thr69, Thr153, Thr175, Thr 181, Ser198, Ser199, Ser202, Thr205, Ser208, Ser210, Thr212, Ser214, Thr217, Thr231, Ser235, Ser237, Ser241, Ser262, Ser285, Ser305, Ser324, Ser352, Ser356, Ser396, Ser400, Thr403, Ser404, Ser409, Ser412, Ser413, Ser416 and Ser422. These sites are among the major abnormal phosphorylation sites of Tau. Phosphorylation on these sites reduces the ability of a given Tau species to promote microtubule self-assembly. Hyperphosphorylated Tau is the major protein of the paired helical filaments (PHFs), which make up the pathological neurofibrillary tangles of Alzheimer’s disease (AD). The PHFs are also found in the lesions of other central nervous system disorders.

PURIFICATION The Rabbit IgG is purified by site-modified Epitope Affinity Purification.	SPECIFICITY This antibody recognizes phosphorylated Serine 202 of human Tau protein. It does not recognize the non-phosphorylated Tau or other phosphorylation sites.
FORMULATION This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.	STORAGE The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity.Avoid repeated freezing-thawing cycles.

Gene ID

4137

Applications/Suggested Working Dilutions

Western Blot

0.1-1 µg/ml

ELISA

0.01-0.1 µg/ml

Immunoprecipitation

2-5µg/ml

IHC

2-10µg/ml

Flow cytometry

5-10µg/ml

品牌介绍

AbboMax美国ABBOMAX公司是全面的抗体供应厂家，目前可提供的抗体种类多达50000多种，几乎覆盖了目前生命科学研究的各个新领域，还提供相关产品，如：所以一抗产品的标记，各种标记二抗等，为免疫学研究工作提供了极大的方便。

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