abbomax/CD136 (RON) (pY1239)/100ug/601-920,abbomax,,abbomax,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：abbomax/CD136 (RON) (pY1239)/100ug/601-920

产品编号：601-920

市场价：¥0.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>标签抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$299.00

品牌： abbomax

公司：abbomax

公司分类：

商品介绍

CD136 (RON) (pY1239)

Macrophage stimulating 1 receptor; CD136; RON

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Product Preparation

A synthetic peptide containing epitope -EPYYS- with a single phosphorylation sites Y1239 of the human CD136.

Background

CD136, a transmembrane receptor tyrosine kinase, also known as Macrophage stimulating 1 receptor (MST1R) and RON (Recepteur d’origine nantais), is a member of the MET proto-oncogene family (63% homology), and is the receptor for macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. Binding of MSP to CD136 stimulates tyrosine phosphorylation on Tyr 1238 and Tyr 1239. This phosphorylation leads to a up-regulation of CD136 catalytic activity and subsequent activation of downstream signaling molecules. In addition, CD136 contains putative autophosphorylation sites on Tyr 1353 and Tyr 1360. RON mediates multiple signaling cascades, such as MAPK, PI3K/AKT, FAK pathways. CD136 activation can also significantly increase C-Src activity. CD136 is a disulfide-linked 180kD heterodimer composed of a 35kD alpha chain and a 150kD beta chain, and is mainly expressed in cells of epithelial origin. CD136 is thought to play a role in early embryonic development and in the inflammatory response as well as implicated in the progression and metastasis of tumors including those of the breast and colon.

PURIFICATION The Rabbit IgG is purified by site-modified Epitope Affinity Purification.	SPECIFICITY This antibody recognizes ~185 kDa of human CD136 protein. It also reacts with mouse and rat.The other species are not tested.
FORMULATION This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.	STORAGE The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity.Avoid repeated freezing-thawing cycles.

Gene ID

4486

Applications/Suggested Working Dilutions

Western Blot

0.1-1 µg/ml

ELISA

0.01-0.1 µg/ml

Immunoprecipitation

2-5µg/ml

IHC

2-10µg/ml

Flow cytometry

5-10µg/ml

品牌介绍

AbboMax美国ABBOMAX公司是全面的抗体供应厂家，目前可提供的抗体种类多达50000多种，几乎覆盖了目前生命科学研究的各个新领域，还提供相关产品，如：所以一抗产品的标记，各种标记二抗等，为免疫学研究工作提供了极大的方便。

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