abbomax/Catenin-beta (pS37)/100ug/602-600,abbomax,,abbomax,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：abbomax/Catenin-beta (pS37)/100ug/602-600

产品编号：602-600

市场价：¥0.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>内参抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$299.00

品牌： abbomax

公司：abbomax

公司分类：

商品介绍

Catenin-beta (pS37)

CTNNB1

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Product Preparation

A synthetic peptide corresponding to the epitope SGIHS witha single phosphorylation site Ser37 of human b-catenin.

Background

Beta-catenin is a cytosolic, 88 kDa, 781 amino acidprotein belongs tothe ß-catenin family.The N-terminus domain, containing the binding site and the phosphorylation sites. Beta-Catenin serves as a link between cytoskeleton actin and transmembrane cadherin(s). It is believed to contribute to tight cell-to-cell adhesion. It can enter the nucleus and interact with the TCF/LEF family of transcription factors, initiating gene expression. Normally, ß-catenin transcriptional activity is suppressed by a Ser/Thr kinase termed GSK3ß and/or Casein Kinase I (CK1). Kinases are constitutively active and phosphorylates ß-catenin at multiple sites, including S33 and S37, Y96, Y228, Y280 etc. Phosphorylation of ß-catenin targets the molecule for degradation via a ubiquination-mediated pathway. GSK3ß activity can be blocked by upstream signaling events such as Wnt-Frizzled interaction. This inhibits GSK3ß, allowing unphosphorylated ß-catenin to enter the nucleus and initiate gene activation. The phosphorylation of beta-catenin might contribute to tumorigenesis.

PURIFICATION The Rabbit IgG is purified by site-modified Epitope Affinity Purification.	SPECIFICITY This antibody recognizes ~88 kDa of human beta-Catenin protein. It also reacts with mouse and rat.The other species are not tested.
FORMULATION This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.	STORAGE The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity.Avoid repeated freezing-thawing cycles.

Gene ID

1499

Applications/Suggested Working Dilutions

Western Blot

0.1-1 µg/ml

ELISA

0.01-0.1 µg/ml

Immunoprecipitation

2-5µg/ml

IHC

2-10µg/ml

Flow cytometry

5-10µg/ml

品牌介绍

AbboMax美国ABBOMAX公司是全面的抗体供应厂家，目前可提供的抗体种类多达50000多种，几乎覆盖了目前生命科学研究的各个新领域，还提供相关产品，如：所以一抗产品的标记，各种标记二抗等，为免疫学研究工作提供了极大的方便。

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