abbomax/Catenin-beta (pS33)/100ug/601-980,abbomax,,abbomax,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：abbomax/Catenin-beta (pS33)/100ug/601-980

产品编号：601-980

市场价：¥0.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>多克隆抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$325.00

品牌： abbomax

公司：abbomax

公司分类：

商品介绍

Catenin-beta (pS33)

CTNNB1

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Product Preparation

A synthetic peptide corresponding to the epitope SGIHS witha single phosphorylation site Ser33 of human b-catenin.

Background

Beta-catenin is a cytosolic, 88 kDa, 781 amino acidprotein belongs tothe ß-catenin family.The N-terminus domain, containing the binding site and the phosphorylation sites. Beta-Catenin serves as a link between cytoskeleton actin and transmembrane cadherin(s). It is believed to contribute to tight cell-to-cell adhesion. It can enter the nucleus and interact with the TCF/LEF family of transcription factors, initiating gene expression. Normally, ß-catenin transcriptional activity is suppressed by a Ser/Thr kinase termed GSK3ß and/or Casein Kinase I (CK1). Kinases are constitutively active and phosphorylates ß-catenin at multiple sites, including S33 and S37, Y96, Y228, Y280 etc. Phosphorylation of ß-catenin targets the molecule for degradation via a ubiquination-mediated pathway. GSK3ß activity can be blocked by upstream signaling events such as Wnt-Frizzled interaction. This inhibits GSK3ß, allowing unphosphorylated ß-catenin to enter the nucleus and initiate gene activation. The phosphorylation of beta-catenin might contribute to tumorigenesis.

PURIFICATION The Rabbit IgG is purified by site-modified Epitope Affinity Purification.	SPECIFICITY This antibody recognizes ~88 kDa of human beta-Catenin protein. It also reacts with mouse and rat.The other species are not tested.
FORMULATION This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.	STORAGE The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity.Avoid repeated freezing-thawing cycles.

Gene ID

1499

Applications/Suggested Working Dilutions

Western Blot

0.1-1 µg/ml

ELISA

0.01-0.1 µg/ml

Immunoprecipitation

2-5µg/ml

IHC

2-10µg/ml

Flow cytometry

5-10µg/ml

品牌介绍

AbboMax美国ABBOMAX公司是全面的抗体供应厂家，目前可提供的抗体种类多达50000多种，几乎覆盖了目前生命科学研究的各个新领域，还提供相关产品，如：所以一抗产品的标记，各种标记二抗等，为免疫学研究工作提供了极大的方便。

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